Poor quality of drinking water has killed and sickens millions of slum residents in developing countries. This work compares drinking water. quality in the selected slums across South-western Geo-political zone of Nigeria. Six states exist in the zone, the six were grouped into three and one in each group was purposively chosen. Worst slum in each state capital was then chosen to represent the state. Water samples were obtained from 5 most used drinking water sources in each selected slum into sterilized bottles between 6-8 am and immediately taken to laboratory for analysis and the results compared with WHO, NAFDAC and SON approved standards and across the study areas too. The results reveal poor quality of drinking water across the region and therefore recommend intervention of international organizations, government as well as residents.