Endometriosis is defined as the presence of endometriotic tissue outside the uterus, with a range of possible areas to be affected, generating a range of symptoms. In more singular cases, there is infiltration of the main nerves of the pelvis, such as the sciatic nerve. As an instrument used to obtain bibliographic data on the subject, the following databases were consulted: Scielo; Medline; PubMed; Virtual Health Library (VHL). Sciatic endometriosis puts pressure on the sciatic nerve, possibly causing pain, numbness, cramping, and a tingling sensation in the lower back, hips, buttocks, thighs, calves, knees, and feet. Patients often experience pain in the back of the leg and it radiates to the heel. Its location usually affects the lateral surface proximal to the greater sciatic foramen. It is necessary to carry out adequate and efficient intervention to avoid possible irreversible neurological injuries. It is understood, therefore, that endometriosis in the sciatic nerve is a rare condition with a complex diagnosis, which requires early diagnosis, effective and individualized treatment, including a multidisciplinary team, and choice of the best option for the patient in question, in attempt to prevent possible sequelae.