Rationale: Breast cancer is a common pathology worldwide on female population, however, in male patients it has a very low incidence, and due to the delay in diagnosis, unfortunately when it is diagnosed, patients are admitted with a great progression of the disease, directly impacting on their survival. Patient concerns: A 78-year-old male patient with diabetes and hypertension who came for evaluation due to the appearance of a tumor on the right breast. Diagnoses: Histopathological study of the tumor was performed, which reported an infiltrating ductal carcinoma without specific pattern, associated with high-grade ductal carcinoma in situ with the next immunohistochemistry: 40% estrogen receptors, 70% progesterone receptors and HER 2 negative. Outcomes. The choice of treatment was the use of adjuvant hormonal therapy combined with surgical excision, however, due to the extent of tumor activity, survival is very low.