Wearable health-care monitoring devices have emerged as crucial tools for continuous health monitoring and personalized medicine. Medical diagnosis tool requires intimate interfaces with our skin to detect the precise bio signals from our body. This paper explores innovative materials and mechanical design approaches aimed at enhancing the performance, comfort, and usability of such devices. There have been many progresses in materials and geometrical design to enhance the stretchability and wearing-comfort, which is essential aspect of wearable medical applications. The integration of advanced materials, and novel geometric design plays animportant role in ensuring the seamless integration of these devices into users' daily lives. The first section of the paper introduces the general technology of wearable electronics and current limitations for medical diagnosis application in terms of accurate interactions. Next section discusses materials, emphasizing the importance of biocompatible and skin-friendly materials for the construction of wearable health-care devices. Special attention is given to the latest advancements in flexible and stretchable materials, enabling the creation of conformable devices that can adapt to the dynamic movements of the human body.Then, we review the mechanical design strategies that focus on optimizing the form factor and structural integrity of wearable devices. Design considerations include the development of lightweight and thin-film structures, as well as the incorporation of modular components to facilitate customization and scalability. At last, we address the integration of sensor technologies with the mechanical framework, highlighting the need for seamless synergy between the device's form and function. This involves the incorporation of miniaturized sensors for vital sign monitoring, motion tracking, and environmental sensing, allowing for a comprehensive health assessment.