With the development of technological revolution, the integration of digital economy and real economy (referred to as digital-real integration) has become an important engine to promote high-quality development of China's economy. By constructing the theoretical framework of digital-real integration affecting high-quality economic development, this paper uses the fixed effect and intermediary effect model to investigate its mechanism on the basis of using the entropy method to measure the development index of the two from 2014 to 2020 in China. The research show that digital-real integration has a double impact on high-quality economic development, one is the direct effect, which is manifested in the obvious heterogeneity between different regions and different economic levels, and the other is the indirect effect by influencing technological innovation, industrial structure upgrading and urbanization process. In this regard, this paper proposes countermeasures to promote digital-real integration from the aspects of top-level design, condition support and regional cooperation, in order to better promote high-quality economic development.