Background: Absenteeism is a significant problem in gaining knowledge, innovation, and skills to achieve personal and professional goals. The absenteeism of medical students from classrooms and clinical settings harms their performance and prolongs the length of their studying. Objective: This study aimed to identify the Prevalence and risk factors Contributed to Absenteeism among medical Students at the Faculty of Medicine, Sudan International University. Methodology: Descriptive cross-sectional design was used. Data were collected by using a self-administered questionnaire. Results: The study findings of the investigated factors influencing absenteeism among the participating medical students reported that the highest mean scores were associated with Poor health conditions (41.1%), transportation factors (24.9%), followed by intention to work more than to study (21%), Job (15.6%), followed by Preparing to other exams and illness (12.5%) and other social factors. In addition, absence in morning lectures (69.1%) is higher than absence at other times of lectures. Conclusion: This study concluded that the most common contributing factors affecting medical students' absenteeism were poor health conditions, transportation, and early lecture time.