In this millennium cancer has become an inevitable chronic disease. Cancer comes along with physiological and psychological barriers in an individual’s life. Cancer diagnosed patients with low resilience and psychological well-being has seemed to be struggling with emotional instability and having difficulty in having coping with its physiological effects and psychological effects. The purpose of the study was to identify the relationship between resilience and psychological well-being among cancer patients and to find out the factors that influence resilience. 16 participants were participated in this study. Karol Ryff’s psychological well-being questionnaire (1989) and Heather’s resilience questionnaire (1984) were used. The statistical analysis was undertaken by Spearman correlation and regression analysis. Thematic analysis also used to generate themes from interviewed data. The result of the study reveals that, there is a positive relationship between resilience and psychological well- being among cancer patients. And fifteen themes were generated from the interviewed data.