Innovation in rural areas has a wide gap with urban areas. It is due to several inhibiting factors such as location, infrastructure, and human resources. In addition, the characteristics of rural areas tend to be varied. For this reason, a rural adaptation model is needed to catch up with innovation. This study uses the literature review method with 22 comprehensive articles that have topics related to rural innovation. As a result, an adaptation model is obtained through three main indicators, i.e., stakeholders, ecosystem, and strategy, each of which has agents who have different tasks. All three have a relationship with each other which is described in the conceptual framework of Rural Adaptability Model toward Stakeholder, Ecosystem, and Strategy (RAMSES). As a result, with a strategy that varies from the results of stakeholder and ecosystem reviews, it is hoped that it can be used as a medium of adaptability in pursuing an innovation in rural areas, so that an idea and creativity can be commercialized and has use value in society (rural innovation).