The article “Social work in economic support for single women raising children in Ho Chi Minh City” focuses on surveying and analyzing the current economic life of single women – a vulnerable subject in the context of urbanization and socio-economic fluctuations. Through the collection of practical data and qualitative analysis, research clarifies the perception of single women about their own economic situation, specific manifestations of economic difficulties in daily life such as precarious income, rising cost of living and childcare, etc lack of stable job opportunities. On the basis of identifying barriers to policies, vocational skills and social support, the article proposes a number of social work solutions to improve the economic capacity of single women, including: strengthening counseling, job connection, vocational training associated with the labor market, etc develop community support networks and promote flexible and practical welfare policies. The study emphasizes the essential role of social work in promoting gender equality, sustainable poverty reduction and ensuring socio-economic benefits for single women raising children in large cities.