Objectives: Comparison of Effectiveness of Ultrasound Therapy and Mulligan’s Movement with Mobilization versus Cyriax’s Deep Transverse Friction in the Management of Lateral Epicondylitis. Design: A true experimental study, in Physiotherapy and rehabilitation centre. Subjects: This study was carried out with 30 patients of age between 30-60 years who are positive for Cozen’s test. Intervention: Experimental Group A (N=15 received Ultrasound Therapy with Mulligan Movement with Mobilization and Control Group B (N=15 received Cyriax Deep Transverse Friction. All patients received treatment for a period of three weeks. Outcomes: Pain, Grip strength and Functional ability was evaluated using Visual Analogue Scale, Patient Rated Tennis Elbow Evaluation Questionnaire and Sphygmomanometer in patients with lateral epicondylitis which were recorded at the base line and at the end of third week. Results: Both the Mulligan’s Movement with Mobilization along with Ultrasound Therapy and Cyriax’s Deep Transverse Friction were found to be significantly effective in the Management of Lateral Epicondylitis. Mulligan’s Movement with Mobilization along with Ultrasound Therapy resulted in greater improvement in comparison to those who received Cyriax’s Deep Transverse Friction. Conclusion: The result of this experimental study demonstrates that the Ultrasound Therapy along with the Mulligan movement with mobilization is an effective treatment program for Lateral epicondylitis patients in reducing pain and improving functional activity and grip strength.