Strategic management accounting (SMA) is a data system for management accounting to assist managers in planning, implementing and evaluating an organization's strategy. However, up to now, there are several completed and systematic studies on the affecting factors and the interactions between the implementation of strategic management accounting as well as operational performance of enterprises. Lack of empirical evidences is a challenging policy makers and business managers. This study employs primary data from a survey of 352 enterprises in Southeast Viet Nam using the Partial Least Squares-Structural Equation Modeling for data analysis and interpretation. The findings of the study revealed that there is a positive linear relationship between implementation of strategic management accounting and operational performance of enterprises. Factors affecting the implementation of strategic management accounting include: enterprise size, applied technology level, management hierarchy, having business strategy, and competition on market.